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Article

Mutation analysis of the HFE gene associated with hereditary hemochromatosis in African Americans.

American journal of hematology - 1 Jul 1998

Monaghan K G, Rybicki B A, Shurafa M, Feldman G L

Abstract excerpt

Homozygosity for the mutation Cys282Tyr in the HFE gene has recently been identified as a cause of hereditary hemochromatosis, a disorder resulting in the inappropriate absorption of iron. Approximately 10% of Caucasians are heterozygous for this mutation; however, the gene frequency in African Americans is unknown. A study of a control population of African Americans was performed to determine the frequency of...

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Identifiers

PMID: 9662273
DOI: 10.1002/(sici)1096-8652(199807)58:3<213::aid-ajh9>3.0.co;2-u

Genes

HFE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation analysis of the HFE gene associated with hereditary hemochromatosis in African Americans.PMID 9662273Read ↗

The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis.Semantic proximity Read ↗

Identification of hemochromatosis gene polymorphisms in chronically transfused patients with sickle cell disease.Semantic proximity Read ↗

Inheritance of two HFE mutations in African Americans: cases with hemochromatosis phenotypes and estimates of hemochromatosis phenotype frequency.Semantic proximity Read ↗

Transferrin receptor mutation analysis in hereditary hemochromatosis patients.Semantic proximity Read ↗

Ethnic differences in the HFE codon 282 (Cys/Tyr) polymorphism.Semantic proximity Read ↗

Prevalence of the C282Y and H63D polymorphisms in a multi-ethnic control population.Semantic proximity Read ↗

HFE mutations in African-American women with non-insulin-dependent diabetes mellitus.Semantic proximity Read ↗

High incidence of the Cys 282 Tyr mutation in the HFE gene in the Irish population ‐implications for haemochromatosisSemantic proximity Read ↗

Mutation analysis of the HFE gene associated with hereditary hemochromatosis in a Venezuelan sample.Semantic proximity Read ↗

HFE gene mutations in coronary atherothrombotic disease.Semantic proximity Read ↗

Mutation analysis of the transferrin receptor-2 gene in patients with iron overload.Semantic proximity Read ↗

Hemochromatosis with HFE gene mutation in a Japanese patient.Semantic proximity Read ↗

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