Article
Mutation analysis of the HFE gene associated with hereditary hemochromatosis in African Americans.
American journal of hematology - 1 Jul 1998
Monaghan K G, Rybicki B A, Shurafa M, Feldman G L
Abstract excerpt
Homozygosity for the mutation Cys282Tyr in the HFE gene has recently been identified as a cause of hereditary hemochromatosis, a disorder resulting in the inappropriate absorption of iron. Approximately 10% of Caucasians are heterozygous for this mutation; however, the gene frequency in African A...
Topics
- Adult
- Aged
- Alleles
- Asian People
- Black People
- DNA
- Female
- Gene Frequency
- HLA Antigens
- Hemochromatosis
- Hemochromatosis Protein
- Heterozygote
- Histocompatibility Antigens Class I