Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inheritance of two HFE mutations in African Americans: cases with hemochromatosis phenotypes and estimates of hemochromatosis phenotype frequency.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jan 2000

Barton J C, Acton R T

Abstract excerpt

PURPOSE: Two unrelated African Americans had hemochromatosis phenotypes and genotypes. We sought to identify origins of their HFE mutations and estimate frequencies of similar cases. METHODS: HFE and HLA genotyping were performed in index cases and family members. HFE genotypes of 1,373 African American controls in five regions were tabulated. RESULTS: Index cases had C282Y/C282Y and C282Y/H63D, respectively;...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Black or African American
Share to Black People

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hemochromatosis

Share to Hemochromatosis Protein

Share to Histocompatibility Antigens Class I

Share to HLA Antigens

Share to Iron Overload

Share to United States

Source

Identifiers

PMID: 11478530
DOI: 10.1097/00125817-200107000-00005

Genes

HFE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inheritance of two HFE mutations in African Americans: cases with hemochromatosis phenotypes and estimates of hemochromatosis phenotype frequency.PMID 11478530Read ↗

Estimates of European American Ancestry in African Americans Using HFE p.C282Y.Semantic proximity Read ↗

HFE hemochromatosis in African Americans: Prevalence estimates of iron overload and iron overload-related disease.Semantic proximity Read ↗

Prevalence of C282Y and H63D mutations in the hemochromatosis (HFE) gene in the United States.Semantic proximity Read ↗

Prevalence of three hereditary hemochromatosis mutant alleles in the Michigan Caucasian population.Semantic proximity Read ↗

Diagnosis of hemochromatosis in family members of probands: a comparison of phenotyping and HFE genotyping.Semantic proximity Read ↗

Hemochromatosis and iron-overload screening in a racially diverse population.Semantic proximity Read ↗

Haplotype analysis of the HFE gene: implications for the origins of hemochromatosis related mutations.Semantic proximity Read ↗

Prevalence and penetrance of HFE mutations in 4865 unselected primary care patients.Semantic proximity Read ↗

HLA-A*03, the hemochromatosis ancestral haplotype, and phenotypes of referred hemochromatosis probands with HFE p.C282Y homozygosity.Semantic proximity Read ↗

Geographic and racial/ethnic differences in HFE mutation frequencies in the Hemochromatosis and Iron Overload Screening (HEIRS) Study.Semantic proximity Read ↗

Effect of Native American ancestry on iron-related phenotypes of Alabama hemochromatosis probands with HFE C282Y homozygosity.Semantic proximity Read ↗

African Americans at risk for increased iron stores or liver disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.