Crystallography and mutagenesis of transketolase: mechanistic implications for enzymatic thiamin catalysis.

doi:10.1016/s0167-4838(98)00082-x

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Article

Crystallography and mutagenesis of transketolase: mechanistic implications for enzymatic thiamin catalysis.

Biochimica et biophysica acta - 29 Jun 1998

Schneider G, Lindqvist Y

Abstract excerpt

The ThDP dependent enzyme transketolase is a convenient model system to study enzymatic thiamin catalysis. Crystallographic studies of the enzyme have identified the ThDP binding fold, the V-conformation of ThDP as the relevant conformation in enzymatic catalysis and details of enzyme-substrate i...

Topics

Apoenzymes
Crystallography, X-Ray
Enzyme Activation
Models, Molecular
Mutation
Protein Binding
Protein Conformation
Protein Structure, Tertiary
Thiamine
Thiamine Pyrophosphate
Transketolase

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