Article
Overexpression of an unstable intrinsic factor-cobalamin receptor in Imerslund-Gräsbeck syndrome.
Gastroenterology - 1 Jul 1998
Eaton D M, Livingston J H, Seetharam B, Puntis J W
Abstract excerpt
Two sisters with Imerslund-Gräsbeck syndrome who presented with clinical features of cobalamin deficiency are described. Intrinsic factor-cobalamin receptor (IFCR) activity and protein levels were determined in ileal biopsy specimens by using radioisotope assay and immunoblotting, respectively. IFCR activities in ileal homogenates expressed as femtomoles of ligand binding per milligram of protein were 38 +/- 4 in...
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