Article
Retrovirus-mediated double transduction of the GTPCH and PTPS genes allows 6-pyruvoyltetrahydropterin synthase-deficient human fibroblasts to synthesize and release tetrahydrobiopterin.
Journal of neurochemistry - 1 Jul 1998
Laufs S, Blau N, Thöny B
Abstract excerpt
The tetrahydrobiopterin (BH4) cofactor is essential for the aromatic amino acid hydroxylases that are involved in phenylalanine degradation and catecholamine and serotonin biosynthesis. Furthermore, BH4 is an essential and limiting cofactor for all types of nitric oxide synthases. BH4 deficiency...
Topics
- Animals
- Biopterins
- COS Cells
- Culture Media
- Fibroblasts
- GTP Cyclohydrolase
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Viral
- Gene Transfer Techniques
- Humans
- Mutation
- Neopterin
- Neurotransmitter Agents
- Phenylalanine
- Phosphorus-Oxygen Lyases
- Pterins
- Retroviridae
- Skin