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Article

Epolones: Novel Sesquiterpene-Tropolones from Fungus OS-F69284 That Induce Erythropoietin in Human Cells

30 May 1998

Abstract excerpt

In the course of our screening for small molecule modulators of erythropoietin gene expression, two novel sesquiterpene tropolones and pycnidone were isolated from a culture of OS-F69284 (ATCC 74390). Their structures were elucidated by extensive 1H and 13C NMR spectroscopic studies and chemical reactions. These compounds induced erythropoietin gene expression 5-fold at a concentration of 1-1.6 microM.

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PMID: 9644066
DOI: 10.1021/np9800506

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