The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis.

doi:10.1074/jbc.273.27.17122

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Article

The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis.

The Journal of biological chemistry - 3 Jul 1998

Bolívar J, Guelman S, Iglesias C, Ortíz M, Valdivia M M

Abstract excerpt

We describe a new human autoimmune antigen in a patient suffering from scleroderma with high levels of antibodies to nucleolus and cytoplasmic antigens. Using a Chinese hamster ovary cell expression library, we have shown that this antigen corresponds to the autosomal Fragile-X-related gene FXR1....

Topics

Amino Acid Sequence
Animals
Apoptosis
Autoantigens
Base Sequence
CHO Cells
Cricetinae
DNA, Complementary
HeLa Cells
Humans
Jurkat Cells
Molecular Sequence Data
Mutation
Protein Processing, Post-Translational
RNA-Binding Proteins
Sequence Homology, Amino Acid

Source

Open in PubMed

Identifiers

PMID: 9642279
DOI: 10.1074/jbc.273.27.17122

Genes

FXR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9642279-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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