Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis.

The Journal of biological chemistry - 3 Jul 1998

Bolívar J, Guelman S, Iglesias C, Ortíz M, Valdivia M M

Abstract excerpt

We describe a new human autoimmune antigen in a patient suffering from scleroderma with high levels of antibodies to nucleolus and cytoplasmic antigens. Using a Chinese hamster ovary cell expression library, we have shown that this antigen corresponds to the autosomal Fragile-X-related gene FXR1. The deduced amino acid sequence from the hamster cDNA is 97, 98, and 58% homologous to the human, mouse, and Xenopus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cricetinae

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to HeLa Cells

Share to Molecular Sequence Data

Share to Mutation

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 9642279
DOI: 10.1074/jbc.273.27.17122

Genes

FXR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis.PMID 9642279Read ↗

Isolation and sequencing of NOP1. A yeast gene encoding a nucleolar protein homologous to a human autoimmune antigen.Semantic proximity Read ↗

Molecular Cloning of a Zinc Finger Autoantigen Transiently Associated with Interphase Nucleolus and Mitotic Centromeres and MidbodiesSemantic proximity Read ↗

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.Semantic proximity Read ↗

Human autoantibody to a novel protein of the nuclear coiled body: immunological characterization and cDNA cloning of p80-coilin.Semantic proximity Read ↗

Different temporal expression of immunodominant Ro60/60 kDa-SSA and La/SSB apotopesSemantic proximity Read ↗

Identification of Human Autoantibodies to the DNA Ligase IV/XRCC4 Complex and Mapping of an Autoimmune Epitope to a Potential Regulatory RegionSemantic proximity Read ↗

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.Semantic proximity Read ↗

Interactions of cellular polypeptides with the cytoplasmic domain of the mouse Fas antigen.Semantic proximity Read ↗

Dissecting the cellular functions of annexin XI using recombinant human annexin XI-specific autoantibodies cloned by phage display.Semantic proximity Read ↗

Nephritogenic Lupus Antibodies Recognize Glomerular Basement Membrane-Associated Chromatin Fragments Released from Apoptotic Intraglomerular CellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.