Article
Gene replacement analysis of the Streptomyces virginiae barA gene encoding the butyrolactone autoregulator receptor reveals that BarA acts as a repressor in virginiamycin biosynthesis.
Journal of bacteriology - 1 Jul 1998
Nakano H, Takehara E, Nihira T, Yamada Y
Abstract excerpt
Virginiae butanolides (VBs), which are among the butyrolactone autoregulators of Streptomyces species, act as a primary signal in Streptomyces virginiae to trigger virginiamycin biosynthesis and possess a specific binding protein, BarA. To clarify the in vivo function of BarA in the VB-mediated s...
Topics
- 4-Butyrolactone
- Amino Acid Sequence
- Gene Transfer Techniques
- Genetic Vectors
- Helix-Turn-Helix Motifs
- Kinetics
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Phenotype
- Recombination, Genetic
- Repressor Proteins
- Streptomyces
- Virginiamycin