Article
Dual functions of DNA repair genes: molecular, cellular, and clinical implications.
BioEssays : news and reviews in molecular, cellular and developmental biology - 1 Feb 1998
Lehmann A R
Abstract excerpt
The complex series of DNA repair pathways that are used to repair damage to cellular DNA employ many different proteins. A substantial number of these have second functions. Defects in these multifunctional proteins in man can lead to widely differing clinical phenotypes depending on which of the functions is affected. This is illustrated most clearly in the transcription factor TFIIH, which is involved in both...
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