Article
Ketoconazole inhibits the metabolism of tolterodine in subjects with deficient CYP2D6 activity.
British journal of clinical pharmacology - 1 Oct 1999
Brynne N, Forslund C, Hallén B, Gustafsson L L, Bertilsson L
Abstract excerpt
AIMS: To investigate the pharmacokinetics and safety of tolterodine and tolterodine metabolites after single-and multiple-dose administration in the absence and presence of ketoconazole, an inhibitor of cytochrome P450 (CYP) 3A4, in healthy volunteers with deficient CYP2D6 activity, i.e. poor metabolisers of debrisoquine. METHODS: Eight healthy volunteers received single oral doses (2 mg) of tolterodine...
Topics
- Adult
- Antifungal Agents
- Benzhydryl Compounds
- Cresols
- Cross-Over Studies
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 CYP3A
- Cytochrome P-450 Enzyme Inhibitors
- Drug Interactions
- Female
- Humans
- Ketoconazole
- Male
- Mixed Function Oxygenases