Article
Association of Sjögren's syndrome with HLA-B8.
Arthritis and rheumatism - 1 Jan 2000
Fye K H, Terasaki P I, Moutsopoulos H, Daniels T E, Michalski J P, Talal N
Abstract excerpt
HLA antigens were examined by microdroplet lymphocyte cytotoxicity in 31 patients with Sjögrens syndrome. Fifty percent of 22 Causcasian patients (7 of 17 females and 4 of 5 males) had HLA-B8, as compared to 21% of 1205 controls (P=0.002). The presence of HLA-B8 was not correlated with parotid salivary flow, keratoconjunctivitis sicca, or focus score. Because of its association with a number of autoimmune...
Topics
- Adolescent
- Adult
- Aged
- Autoimmune Diseases
- California
- Cytotoxicity Tests, Immunologic
- Female
- Genes
- Genotype
- HLA Antigens
- Histocompatibility Antigens
- Humans