Article
Mutations in the homeobox gene HESX1/Hesx1 associated with septo-optic dysplasia in human and mouse.
Nature genetics - 1 Jun 1998
Dattani M T, Martinez-Barbera J P, Thomas P Q, Brickman J M, Gupta R, Mårtensson I L, Toresson H, Fox M, Wales J K, Hindmarsh P C, Krauss S, Beddington R S, Robinson I C
Abstract excerpt
During early mouse development the homeobox gene Hesx1 is expressed in prospective forebrain tissue, but later becomes restricted to Rathke's pouch, the primordium of the anterior pituitary gland. Mice lacking Hesx1 exhibit variable anterior CNS defects and pituitary dysplasia. Mutants have a reduced prosencephalon, anopthalmia or micropthalmia, defective olfactory development and bifurcations in Rathke's pouch....
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