Article
Molecular genetics of septo-optic dysplasia.
Hormone research - 1 Jan 2000
Dattani M L, Martinez-Barbera J, Thomas P Q, Brickman J M, Gupta R, Wales J K, Hindmarsh P C, Beddington R S, Robinson I C
Abstract excerpt
Septo-optic dysplasia (SOD) is a highly variable condition characterized by midline neurological abnormalities associated with pituitary hypoplasia and optic nerve hypoplasia. The aetiology is unknown. Mutant mice, in which a novel homeobox gene, Hesx1, has been disrupted, exhibit a phenotype that resembles the phenotype of SOD. We therefore wished to explore the possibility that this gene is implicated in SOD....
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