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Article

Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae.

Proceedings of the National Academy of Sciences of the United States of America - 26 May 1998

Ludin K, Jiang R, Carlson M

Abstract excerpt

The Snf1 protein kinase family has been conserved in eukaryotes. In the yeast Saccharomyces cerevisiae, Snf1 is essential for transcription of glucose-repressed genes in response to glucose starvation. The direct interaction between Snf1 and its activating subunit, Snf4, within the kinase complex is regulated by the glucose signal. Glucose inhibition of the Snf1-Snf4 interaction depends on protein phosphatase 1...

Topics

Fungal Proteins
Gene Expression Regulation, Fungal
Glucose
Mutation
Phosphoprotein Phosphatases
Protein Phosphatase 1
Protein Serine-Threonine Kinases
Saccharomyces cerevisiae

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9600950
DOI: 10.1073/pnas.95.11.6245
PMCID: PMC27646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-9600950-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae.PMID 9600950Read ↗

Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase.Semantic proximity Read ↗

REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae.Semantic proximity Read ↗

The REG2 gene of Saccharomyces cerevisiae encodes a type 1 protein phosphatase-binding protein that functions with Reg1p and the Snf1 protein kinase to regulate growth.Semantic proximity Read ↗

Heterotrimer-independent regulation of activation-loop phosphorylation of Snf1 protein kinase involves two protein phosphatases.Semantic proximity Read ↗

PP1 phosphatase-binding motif in Reg1 protein of Saccharomyces cerevisiae is required for interaction with both the PP1 phosphatase Glc7 and the Snf1 protein kinase.Semantic proximity Read ↗

Functional analysis of the yeast Glc7-binding protein Reg1 identifies a protein phosphatase type 1-binding motif as essential for repression of ADH2 expression.Semantic proximity Read ↗

Protein kinase A contributes to the negative control of Snf1 protein kinase in Saccharomyces cerevisiae.Semantic proximity Read ↗

Snf1 promotes phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 by activating Gcn2 and inhibiting phosphatases Glc7 and Sit4.Semantic proximity Read ↗

Protein kinase Snf1 is involved in the proper regulation of the unfolded protein response in Saccharomyces cerevisiae.Semantic proximity Read ↗

Roles of two protein phosphatases, Reg1-Glc7 and Sit4, and glycogen synthesis in regulation of SNF1 protein kinase.Semantic proximity Read ↗

The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex.Semantic proximity Read ↗

Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit.Semantic proximity Read ↗

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