Identifying Hereditary Nonpolyposis Colorectal Cancer

Abstract excerpt

The recent discovery of the genetic basis of certain familial aggregations of colorectal cancer validated 90 years of clinical observation suggesting that such aggregations are hereditary.1 It also promised the ability to detect asymptomatic carriers of the deleterious genes, with attendant gains in the control of cancer. Our ability to act on that promise has been held back by the need for answers to two...

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