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Article

Simulated microgravity conditions enhance differentiation of cultured PC12 cells towards the neuroendocrine phenotype.

In vitro cellular & developmental biology. Animal - 1 Apr 1998

Lelkes P I, Galvan D L, Hayman G T, Goodwin T J, Chatman D Y, Cherian S, Garcia R M, Unsworth B R

Abstract excerpt

We are studying microenvironmental cues which contribute to neuroendocrine organ assembly and tissue-specific differentiation. As our in vitro model, we cultured rat adrenal medullary PC12 pheochromocytoma cells in a novel cell culture system, the NASA rotating wall vessel (RWV) bioreactors. This "simulated microgravity" environment in RWV bioreactors, characterized by randomizing gravitational vectors and...

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PMID: 9590505
DOI: 10.1007/s11626-998-0008-y

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PNMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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