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RCCS Bioreactor-Based Modelled Microgravity Induces Significant Changes on<i>In Vitro</i>3D Neuroglial Cell Cultures

1 Jan 2015

Abstract excerpt

We propose a human-derived neuro-/glial cell three-dimensional in vitro model to investigate the effects of microgravity on cell-cell interactions. A rotary cell-culture system (RCCS) bioreactor was used to generate a modelled microgravity environment, and morphofunctional features of glial-like GL15 and neuronal-like SH-SY5Y cells in three-dimensional individual cultures (monotypic aggregates) and cocultures...

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PMID: 25654124
DOI: 10.1155/2015/754283

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