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Article

An autoimmune response causes transmissible spongiform encephalopathies.

Medical hypotheses - 1 Mar 1998

Axelrad J

Abstract excerpt

Misfolded prion protein (PrP) is generally accepted as causing transmissible spongiform encephalopathies (TSEs) by aligning alongside normal host prion protein and inducing it to change to the misfolded configuration. This paper disputes this theory, and proposes that, rather than causing TSEs, misfolded PrP is the result of an autoimmune response to the host PrP, a component both of nerve cells and of...

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Source

Identifiers

PMID: 9578331
DOI: 10.1016/s0306-9877(98)90027-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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