Article
Examination of new and reported data of the DRD3/MscI polymorphism: no support for the proposed association with schizophrenia.
Molecular psychiatry - 1 Mar 1998
Hawi Z, McCabe U, Straub R E, O'Neill A, Kendler K S, Walsh D, Gill M
Abstract excerpt
The dopamine D3 (DRD3) receptor gene has been implicated in the aetiology of schizophrenia as a candidate gene since it combines both the dopamine receptor and limbic hypotheses of the disease. Previous association studies of a DRD3/MscI polymorphism suggested an increased frequency of homozygosity at the DRD3 receptor gene in schizophrenia. Homozygosity appeared to be particularly frequent in male patients,...
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