Article
Examination of new and reported data of the DRD3/MscI polymorphism: no support for the proposed association with schizophrenia.
Molecular psychiatry - 1 Mar 1998
Hawi Z, McCabe U, Straub R E, O'Neill A, Kendler K S, Walsh D, Gill M
Abstract excerpt
The dopamine D3 (DRD3) receptor gene has been implicated in the aetiology of schizophrenia as a candidate gene since it combines both the dopamine receptor and limbic hypotheses of the disease. Previous association studies of a DRD3/MscI polymorphism suggested an increased frequency of homozygosity at the DRD3 receptor gene in schizophrenia. Homozygosity appeared to be particularly frequent in male patients,...
Topics
- Alleles
- DNA
- Deoxyribonucleases, Type II Site-Specific
- Disease Susceptibility
- Dopamine
- Ethnicity
- Female
- Gene Frequency
- Genotype
- Humans
- Ireland