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Article

Cloning and expression of the beta- and gamma-subunits of the human epithelial sodium channel

1 May 1995

Abstract excerpt

Amiloride-sensitive Na+ channels are an important component of the Na+ reabsorption pathway in a number of epithelia. Here we report the cloning and characterization of cDNAs encoding two subunits of the human kidney epithelial Na+ channel (beta- and gamma-hENaC). Their predicted amino acid sequences were highly homologous (83-85% identical) to the corresponding subunits reported from rat colon (beta- and...

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PMID: 7762608
DOI: 10.1152/ajpcell.1995.268.5.c1157

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