Article
Association of HLA phenotype and response to interferon-alpha in patients with chronic myelogenous leukemia.
Leukemia - 1 Apr 1998
Cortes J, Fayad L, Kantarjian H, O'Brien S, Lee M S, Talpaz M
Abstract excerpt
Twenty to 25% of patients with chronic myelogenous leukemia (CML) treated with interferon-alpha (IFN-A) achieve a complete cytogenetic response (CCR). However, cells bearing rearrangement of BCR/ABL can still be detected many years after achieving a CCR despite the absence of clinical evidence of active disease. It has been suggested that the disease is kept in a dormant state by immune mechanisms. How this is...
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