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Article

A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon α.

Haematologica - 1 Jan 2010

Kreil Sebastian, Waghorn Katherine, Ernst Thomas, Chase Andrew, White Helen, Hehlmann Rüdiger, Reiter Andreas, Hochhaus Andreas, Cross Nicholas C P

Abstract excerpt

Interferon alpha (IFN) induces variable responses in chronic myeloid leukemia (CML), with 8-30% of early chronic phase cases achieving a complete cytogenetic response. We hypothesized that polymorphic differences in genes encoding IFN signal transduction components might account for different pat...

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Topics

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Share to Aged, 80 and over
Share to Drug Resistance, Neoplasm
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon-alpha

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Signal Transduction

Share to STAT3 Transcription Factor

Share to Young Adult

Source

Open in PubMed Open full text

Identifiers

PMID: 20065083
DOI: 10.3324/haematol.2009.011510
PMCID: PMC2805737

Genes

STAT3
IFNAR1
IFNAR2
JAK1
STAT1
TYK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20065083-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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