Article
Antigenic stimulation by BCG vaccine as an in vivo driving force for SIV replication and dissemination.
Nature medicine - 1 Apr 1998
Cheynier R, Gratton S, Halloran M, Stahmer I, Letvin N L, Wain-Hobson S
Abstract excerpt
The impact of antigenic stimulation on the dynamics of simian immunodeficiency virus (SIV) replication was studied following repeated intravenous BCG inoculation of a SIV infected macaque. At the site of a delayed type hypersensitivity reaction to purified protein derivative of M. tuberculosis, a distinctive SIV variant was noted, probably as a result of the infiltration of activated antigen-specific T cell...
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