Evidence for Multiple Determinants of the Body Mass Index: The National Heart, Lung, and Blood Institute Family Heart Study

Abstract excerpt

The body mass index (BMI) is a complex phenotype representing the amount of fat mass, lean mass, body build and proportions, and it is likely to be affected by various metabolic processes, hormonal effects, energy intake and expenditure, and interactions within and among these broad categories of etiologic factors. Nonetheless, several previous studies have reported evidence for major gene segregation for the BMI...

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