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Article

Structure-based methods to predict mutational resistance to diarylpyrimidine non-nucleoside reverse transcriptase inhibitors.

Journal of molecular graphics & modelling - 1 Jan 2018

Azeem Syeda Maryam, Muwonge Alecia N, Thakkar Nehaben, Lam Kristina W, Frey Kathleen M

Abstract excerpt

Resistance to non-nucleoside reverse transcriptase inhibitors (NNRTIs) is a leading cause of HIV treatment failure. Often included in antiviral therapy, NNRTIs are chemically diverse compounds that bind an allosteric pocket of enzyme target reverse transcriptase (RT). Several new NNRTIs incorporate flexibility in order to compensate for lost interactions with amino acid conferring mutations in RT. Unfortunately,...

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Identifiers

PMID: 29156381
DOI: 10.1016/j.jmgm.2017.10.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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