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Article

Glomerular Basement Membrane

1 Apr 1998

Abstract excerpt

Glomerular basement membrane (GBM) plays a crucial function in the ultrafiltration of blood plasma by the kidney. This function is impaired in Alport syndrome, a hereditary disorder that is caused by mutations in the gene encoding type IV collagen, but it is not known how the mutations lead to a defective GBM. In the present study, the supramolecular organization of type IV collagen of GBM was investigated. This...

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Identifiers

PMID: 9535854
DOI: 10.1074/jbc.273.15.8767

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