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Article

Persistence and Expression of the Herpes Simplex Virus Genome in the Absence of Immediate-Early Proteins

1 Apr 1998

Abstract excerpt

The immediate-early (IE) proteins of herpes simplex virus (HSV) function on input genomes and affect many aspects of host cell metabolism to ensure the efficient expression and regulation of the remainder of the genome and, subsequently, the production of progeny virions. Due to the many and varied effects of IE proteins on host cell metabolism, their expression is not conducive to normal cell function and...

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PMID: 9525658
DOI: 10.1128/jvi.72.4.3307-3320.1998

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