Article
Multiple myeloma: the cells of origin--a two-way street.
Leukemia - 1 Feb 1998
Berenson J R, Vescio R A, Said J
Abstract excerpt
Multiple myeloma results from an interplay between the monoclonal malignant plasma cells and supporting nonmalignant cells in the bone marrow. Recent studies suggest that the final transforming event in this B cell disorder occurs at a late stage of B cell differentiation based on the characteristics of the immunoglobulin genes expressed by the malignant clone as well as surface markers present on the tumor...
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