TheCDKN2ATumor-Suppressor Locus — A Tale of Two Proteins

Abstract excerpt

In this issue of the Journal, Monzon et al. report the occurrence of germ-line mutations of the CDKN2A gene in patients with multiple primary melanomas.1 CDKN2A, a tumor-suppressor gene, has a central role in regulating cell division.The loss of function of tumor-suppressor genes is a key event in the multistep process that transforms a normal cell into a cancer cell. In normal cells, the proteins that arise from...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cancer-related Molecular Pathways
• Share to Epigenetics and DNA Methylation
• Share to Ubiquitin and proteasome pathways