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Article

Collagen type VI gene expression in the skin of trisomy 21 fetuses*1

1 Mar 1998

Abstract excerpt

OBJECTIVE: To determine whether the mechanism for the retention of interstitial fluid in trisomy 21 fetuses presenting with nuchal translucency at 10-14 weeks' gestation is an alteration in the composition of collagen type VI, which is normally a triple helix formed of three single chains, alpha1, alpha2, and alpha3. The genes responsible for the alpha1 and alpha2 chains, COL6A1 and COL6A2, are located on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 9491853
DOI: 10.1016/s0029-7844(97)00697-2

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