Article
The application of a homologous recombination assay revealed amino acid residues in an LTR-retrotransposon that were critical for integration.
Journal of virology - 1 Feb 1998
Atwood A, Choi J, Levin H L
Abstract excerpt
Retroviruses and their relatives, the LTR-retrotransposons, possess an integrase protein (IN) that is required for the insertion of reverse transcripts into the genome of host cells. Schizosaccharomyces pombe is the host of Tf1, an LTR-retrotransposon with integration activity that can be studied by using techniques of yeast genetics. In this study, we sought to identify amino acid substitutions in Tf1 that...
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