[Molecular pathology of muscle diseases].

Abstract excerpt

The most significant pathologic finding in muscular dystrophy(MD) is muscle fiber necrosis followed by regeneration. A membrane hypothesis to explain fiber necrosis seems to be confirmed by the discovery of dystrophin and dystrophin-associated glycoprotein (DAG); both are located along the muscle surface membrane. However the mechanism of muscle fiber degeneration cannot be fully explained by the membrane theory...

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