Article
FRAXA and FRAXE: evidence against segregation distortion and for an effect of intermediate alleles on learning disability.
Proceedings of the National Academy of Sciences of the United States of America - 20 Jan 1998
Teague J W, Morton N E, Dennis N R, Curtis G, McKechnie N, Macpherson J N, Murray A, Pound M C, Sharrock A J, Youings S A, Jacobs P A
Abstract excerpt
There have been several claims of segregation distortion (meiotic drive) for loci associated with diseases caused by trinucleotide repeats, leading us to test for this phenomenon in a large study of the X-linked loci FRAXA and FRAXE. We found no evidence of meiotic drive in females and no convincing evidence in males, where the limitation of risk to daughters creates a testing bias for alleles of interest....
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