Article
Cytotoxic and genotoxic effects of 4-hydroxynonenal in cerebral endothelial cells.
Mutation research - 28 Nov 1997
Karlhuber G M, Bauer H C, Eckl P M
Abstract excerpt
Oxygen free radicals are produced in the central nervous system (CNS) as a consequence of normal physiological metabolic reactions of neuronal cells, but there is evidence accumulating that they are also implicated in the processes leading to a number of pathological changes in the brain. A general mechanism whereby oxygen free radicals induce tissue damage is lipid peroxidation (LPO), which generates a large...
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