Article
Ras is an essential component for notochord formation during ascidian embryogenesis.
Mechanisms of development - 1 Nov 1997
Nakatani Y, Nishida H
Abstract excerpt
In ascidian embryos, inductive interactions are necessary for the fate specification of notochord cells. Previous studies have shown that notochord induction occurs at the 32-cell stage and that basic fibroblast growth factor (bFGF) has notochord-inducing activity in ascidian embryos. In vertebrate, it is known that bFGF receptors have tyrosine kinase domain and the signaling pathway is mediated by the small-GTP...
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