Mucosal and parenteral vaccination against acute and latent murine cytomegalovirus (MCMV) infection by using an attenuated MCMV mutant.

doi:10.1128/JVI.72.1.442-451.1998

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Article

Mucosal and parenteral vaccination against acute and latent murine cytomegalovirus (MCMV) infection by using an attenuated MCMV mutant.

Journal of virology - 1 Jan 1998

MacDonald M R, Li X Y, Stenberg R M, Campbell A E, Virgin H W

Abstract excerpt

We used a live attenuated murine cytomegalovirus (MCMV) mutant to analyze mechanisms of vaccination against acute and latent CMV infection. We selected MCMV mutant RV7 as a vaccine candidate since this virus grows well in tissue culture but is profoundly attenuated for growth in normal and severe...

Topics

Animals
B-Lymphocytes
CD8-Positive T-Lymphocytes
Female
Herpesviridae Infections
Humans
Immunity, Mucosal
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Muromegalovirus
Mutation
Receptors, Interferon
Spleen
Vaccination
Vaccines, Attenuated

Source

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Identifiers

PMID: 9420244
DOI: 10.1128/JVI.72.1.442-451.1998
PMCID: PMC109393

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9420244-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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