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Article

Mucosal and parenteral vaccination against acute and latent murine cytomegalovirus (MCMV) infection by using an attenuated MCMV mutant.

Journal of virology - 1 Jan 1998

MacDonald M R, Li X Y, Stenberg R M, Campbell A E, Virgin H W

Abstract excerpt

We used a live attenuated murine cytomegalovirus (MCMV) mutant to analyze mechanisms of vaccination against acute and latent CMV infection. We selected MCMV mutant RV7 as a vaccine candidate since this virus grows well in tissue culture but is profoundly attenuated for growth in normal and severe combined immunodeficient (SCID) mice (V. J. Cavanaugh et al., J. Virol. 70:1365-1374, 1996). BALB/c mice were...

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Identifiers

PMID: 9420244
DOI: 10.1128/JVI.72.1.442-451.1998
PMCID: PMC109393

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