Article
Sustainable cutaneous gene delivery.
Nature biotechnology - 1 Dec 1997
Deng H, Lin Q, Khavari P A
Abstract excerpt
Durable gene delivery to human skin is necessary for lasting correction of human genetic skin disease. Current cutaneous gene-delivery strategies, however, have achieved only transient gene expression, often only within a small percentage of tissue cells. The recent inability to sustain phenotypic correction of human genetic skin disease due to loss of therapeutic gene expression in regenerated epidermal tissue...
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