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Article

Lack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid Leukemias

1 Jan 1998

Abstract excerpt

Interferon consensus sequence binding protein (ICSBP) was first identified as a transcription factor of the interferon (IFN) regulatory factor family (IRF) which regulates expression of IFN-dependent genes by binding to DNA at specific sites, IFN-stimulated responsive elements. Analysis of ICSBP-deficient mice showed hematologic alterations similar to chronic myelogenous leukemia (CML) in humans and suggested a...

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Identifiers

PMID: 9414265
DOI: 10.1182/blood.v91.1.22

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Lack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid LeukemiasPMID 9414265Read ↗

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Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.Semantic proximity Read ↗

Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative DisorderSemantic proximity Read ↗

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Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemiaSemantic proximity Read ↗

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Roles of Interferon Regulatory Factors in Chronic Myeloid LeukemiaSemantic proximity Read ↗

Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2Semantic proximity Read ↗

Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence–Binding ProteinSemantic proximity Read ↗

The Interferon Consensus Sequence-binding Protein (ICSBP/IRF8) Represses PTPN13 Gene Transcription in Differentiating Myeloid CellsSemantic proximity Read ↗

The Interferon Consensus Sequence-binding Protein Activates Transcription of the Gene Encoding Neurofibromin 1Semantic proximity Read ↗

ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cellsSemantic proximity Read ↗

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