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Article

Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia

1 Jun 2001

Abstract excerpt

Mice deficient in the interferon consensus sequence binding protein (ICSBP) develop a disease resembling chronic myeloid leukemia (CML), which in humans is caused by the BCR/ABL oncoprotein. Interferon-alpha (IFN-alpha) induces ICSBP expression and is an effective therapy for CML. This study examined whether enforced expression of ICSBP might antagonize BCR/ABL-induced leukemia; results demonstrated that...

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PMID: 11369642
DOI: 10.1182/blood.v97.11.3491

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Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemiaPMID 11369642Read ↗

Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative DisorderSemantic proximity Read ↗

Interferon consensus sequence binding protein (ICSBP; IRF-8) antagonizes BCR/ABL and down-regulates bcl-2Semantic proximity Read ↗

Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-αSemantic proximity Read ↗

Review: ICSBP/IRF-8: Its Regulatory Roles in the Development of Myeloid CellsSemantic proximity Read ↗

Regulation of Apoptosis in Myeloid Cells by Interferon Consensus Sequence–Binding ProteinSemantic proximity Read ↗

ICSBP/IRF-8 inhibits mitogenic activity of p210 Bcr/Abl in differentiating myeloid progenitor cellsSemantic proximity Read ↗

Suppression of interferon (IFN)-inducible genes and IFN-mediated functional responses in BCR-ABL-expressing cells.Semantic proximity Read ↗

Human interferon consensus sequence binding protein is a negative regulator of enhancer elements common to interferon-inducible genes.Semantic proximity Read ↗

Roles of Interferon Regulatory Factors in Chronic Myeloid LeukemiaSemantic proximity Read ↗

Lack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid LeukemiasSemantic proximity Read ↗

Acceleration of chronic myeloproliferation by enforced expression of Meis1 or Meis3 in Icsbp-deficient bone marrow cells.Semantic proximity Read ↗

Constitutive activation of SHP2 in mice cooperates with ICSBP deficiency to accelerate progression to acute myeloid leukemiaSemantic proximity Read ↗

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