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Article

Length of uninterrupted CGG repeats determines instability in the FMR1 gene.

Nature genetics - 1 Sept 1994

Eichler E E, Holden J J, Popovich B W, Reiss A L, Snow K, Thibodeau S N, Richards C S, Ward P A, Nelson D L

Abstract excerpt

Analysis of 84 human X chromosomes for the presence of interrupting AGG trinucleotides within the CGG repeat tract of the FMR1 gene revealed that most alleles possess two interspersed AGGs and that the longest tract of uninterrupted CGG repeats is usually found at the 3' end. Variation in the length of the repeat appears polar. Alleles containing between 34 and 55 repeats, with documented unstable transmissions,...

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Source

Identifiers

PMID: 7987398
DOI: 10.1038/ng0994-88

Genes

FMR1

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Related research

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Length of uninterrupted CGG repeats determines instability in the FMR1 gene.PMID 7987398Read ↗

Population survey of the human FMR1 CGG repeat substructure suggests biased polarity for the loss of AGG interruptions.Semantic proximity Read ↗

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Re-examination of factors associated with expansion of CGG repeats using a single nucleotide polymorphism in FMR1.Semantic proximity Read ↗

Fragile X CGG repeat structures among African-Americans: identification of a novel factor responsible for repeat instability.Semantic proximity Read ↗

Fragile X AGG analysis provides new risk predictions for 45-69 repeat alleles.Semantic proximity Read ↗

Fragile X gene instability: anchoring AGGs and linked microsatellites.Semantic proximity Read ↗

The role of AGG interruptions in the transcription of FMR1 premutation alleles.Semantic proximity Read ↗

Mechanisms of the FMR1 Repeat Instability: How Does the CGG Sequence Expand?Semantic proximity Read ↗

Frequency and stability of the fragile X premutation.Semantic proximity Read ↗

Sequence analysis of the fragile X trinucleotide repeat: implications for the origin of the fragile X mutation.Semantic proximity Read ↗

Expansion of the fragile X CGG repeat in females with premutation or intermediate alleles.Semantic proximity Read ↗

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