Length of uninterrupted CGG repeats determines instability in the FMR1 gene.

doi:10.1038/ng0994-88

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Article

Length of uninterrupted CGG repeats determines instability in the FMR1 gene.

Nature genetics - 1 Sept 1994

Eichler E E, Holden J J, Popovich B W, Reiss A L, Snow K, Thibodeau S N, Richards C S, Ward P A, Nelson D L

Abstract excerpt

Analysis of 84 human X chromosomes for the presence of interrupting AGG trinucleotides within the CGG repeat tract of the FMR1 gene revealed that most alleles possess two interspersed AGGs and that the longest tract of uninterrupted CGG repeats is usually found at the 3' end. Variation in the len...

Topics

Base Sequence
DNA
Fragile X Mental Retardation Protein
Humans
Male
Models, Genetic
Molecular Sequence Data
Mutation
Nerve Tissue Proteins
RNA-Binding Proteins
Repetitive Sequences, Nucleic Acid
X Chromosome

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