Article
A high prevalence of HLA-H 845A mutations in hemochromatosis patients and the normal population in eastern England.
Blood cells, molecules & diseases - 1 Aug 1997
Willis G, Jennings B A, Goodman E, Fellows I W, Wimperis J Z
Abstract excerpt
We have examined normal individuals and all the patients currently being treated for hemochromatosis at the Norfolk and Norwich hospital for mutations in the HLA-H gene. We found a gene frequency in 200 normal subjects for teh 845A (C282Y) allele of 0.085, corresponding to a carrier frequency of...
Topics
- Alleles
- Amino Acid Substitution
- England
- Female
- Gene Frequency
- HLA Antigens
- Hemochromatosis
- Hemochromatosis Protein
- Heterozygote
- Histocompatibility Antigens Class I
- Homozygote
- Humans
- Linkage Disequilibrium
- Male
- Membrane Proteins
- Point Mutation
- Polymerase Chain Reaction
- Reference Values