Article
La autoantigen binding to a 5' cis-element of rubella virus RNA correlates with element function in vivo.
Gene - 12 Nov 1997
Duncan R C, Nakhasi H L
Abstract excerpt
Rubella virus genomic RNA contains a 5' stem-loop (5'(+) SL) which is required for efficient translation and replication. The La autoantigen previously was shown to bind this RNA sequence in vitro. Results reported here demonstrate that this cellular RNA-binding protein binds to the RV 5' SL RNA with sufficient specificity for the binding to occur in the presence of excess total cellular RNA. Further, the...
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