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Article

La Protein Can Simultaneously Bind to Both 3′- and 5′-Noncoding Regions of Japanese Encephalitis Virus Genome

7 Feb 2011

Abstract excerpt

Japanese encephalitis virus (JEV) genome is a single-stranded, positive-sense RNA with noncoding regions (NCRs) of 95 and 585 bases at its 5' and 3' ends, respectively. These may interact with viral or host proteins important for viral replication. We have previously shown that La protein binds the 3'-stem-loop (SL) structure of JEV 3'-NCR. Using electrophoretic mobility shift and ultraviolet crosslinking assays,...

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PMID: 21294637
DOI: 10.1089/dna.2010.1114

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