Article
Molecular evidence that most but not all carcinosarcomas of the uterus are combination tumors.
Cancer research - 1 Dec 1997
Wada H, Enomoto T, Fujita M, Yoshino K, Nakashima R, Kurachi H, Haba T, Wakasa K, Shroyer K R, Tsujimoto M, Hongyo T, Nomura T, Murata Y
Abstract excerpt
The pathogenesis of carcinosarcoma is still a subject of controversy. In the present study, molecular techniques were applied to determine the pathogenesis of uterine carcinosarcomas. The patterns of chromosome X inactivation were analyzed, targeting a portion of exon 1 of the human androgen receptor (HUMARA) in malignant epithelial and mesenchymal components. The presence of p53 and K-ras mutations were also...
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