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Article

Effects of dimethyl sulfoxide on apolipoprotein A-I in the human hepatoma cell line, HepG2.

Journal of lipid research - 1 Oct 1997

Tam S P, Zhang X, Cuthbert C, Wang Z, Ellis T

Abstract excerpt

Exposure of HepG2 cells to 1% (v/v) dimethyl sulfoxide (DMSO), an effective free radical scavenger, for 24 h resulted in a 2-fold increase in the levels of apolipoprotein (apo) A-I mRNA and secreted protein, with no significant change in apoA-II, apoB, and apoE mRNA and protein levels. The induction of apoA-I was accompanied by a 50% increase in secreted HDL. Nuclear run-off assays indicated that the...

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PMID: 9374131

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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