Article
Low multiplicity cytomegalovirus infection of human aortic smooth muscle cells increases levels of major histocompatibility complex class I antigens and induces a proinflammatory cytokine milieu in the absence of cytopathology.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation - 1 Oct 1997
Arkonac B, Mauck K A, Chou S, Hosenpud J D
Abstract excerpt
BACKGROUND: Cytomegalovirus has been implicated in the development of allograft vasculopathy in heart transplant recipients. Given that allograft vasculopathy is a form of chronic rejection, it is conceivable that cytomegalovirus somehow alters the allogeneic response to the vasculature. Prior wo...
Topics
- Antigens, Viral
- Aortic Diseases
- Cells, Cultured
- Chronic Disease
- Coloring Agents
- Coronary Disease
- Culture Media
- Cytokines
- Cytomegalovirus
- Cytomegalovirus Infections
- Cytopathogenic Effect, Viral
- DNA, Viral
- Fibroblasts