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Murine Cytomegalovirus Infection Increases Aortic Expression of Proatherosclerotic Genes

3 Feb 2004

Abstract excerpt

BACKGROUND: The possible etiologic role of infection in cardiovascular disease is still debated. Having previously demonstrated that murine cytomegalovirus (MCMV) infection of apolipoprotein (apo) E-/- mice increases atherosclerotic lesion size, we determined if MCMV infection produces proatherogenic changes in aortic gene expression. Additionally, in cholesterol-fed C57BL/6J mice, we examined the effects of MCMV...

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PMID: 14757699
DOI: 10.1161/01.cir.0000112585.47513.45

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