Article
Evaluation of different lymphoid tissue sources for the construction of human immunoglobulin gene libraries.
Immunotechnology : an international journal of immunological engineering - 1 Oct 1997
Yip Y L, Hawkins N J, Clark M A, Ward R L
Abstract excerpt
BACKGROUND: Phage display technology allows the isolation of novel human monoclonal antibodies. The technology relies on the construction of a recombinant antibody library and its display on phage particles. The quality of an antibody library is affected by several factors including the size, diversity and source of immunoglobulin genes. OBJECTIVE: The aim of the project was to determine the best tissue source...
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