Article
X-linked situs abnormalities result from mutations in ZIC3.
Nature genetics - 1 Nov 1997
Gebbia M, Ferrero G B, Pilia G, Bassi M T, Aylsworth A, Penman-Splitt M, Bird L M, Bamforth J S, Burn J, Schlessinger D, Nelson D L, Casey B
Abstract excerpt
Vertebrates position unpaired organs of the chest and abdomen asymmetrically along the left-right (LR) body axis. Each structure comes to lie non-randomly with respect to the midline in an overall position designated situs solitus, exemplified in humans by placement of the heart, stomach and spleen consistently to the left. Aberrant LR axis development can lead to randomization of individual organ position (situs...
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