Article
The role of MMAC1 mutations in early-onset breast cancer: causative in association with Cowden syndrome and excluded in BRCA1-negative cases.
American journal of human genetics - 1 Nov 1997
Tsou H C, Teng D H, Ping X L, Brancolini V, Davis T, Hu R, Xie X X, Gruener A C, Schrager C A, Christiano A M, Eng C, Steck P, Ott J, Tavtigian S V, Peacocke M
Abstract excerpt
Cowden syndrome (CS) is an autosomal dominant disorder associated with the development of hamartomas and benign tumors in a variety of tissues, including the skin, thyroid, breast, endometrium, and brain. It has been suggested that women with CS are at increased risk for breast cancer. A locus for CS was recently defined on chromosome 10 in 12 families, resulting in the identification of the CS critical interval,...
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